SHIRO Made from 100% Japanese ingredient to ensure powerful whitening effect from within. Studies claim that Glutathione reduces melanin synthesis and inhibits tyrosinase activity which is the contributory factor in dark skin coloration. It also helps the liver’s health and function in detoxifying our body, that is why glutathione has the highest concentration in the liver. Our Reduced L-Glutathione (GSH) is manufactured by a Japanese company using a patented fermentation.